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Pipeline Overview

Leveraging its platform technology, Oxysterol Therapeutics®, MAX BioPharma continues to identify semi-synthetic oxysterol analogues with potential as drug candidates for treating several debilitating and fatal disorders. These oxysterols target cellular mechanisms that are drivers of human disease. Our oxysterol candidates were handpicked for superior efficacy and favorable drug-like pharmacokinetic and safety profiles. Two candidates are currently our main focus: Oxy133, a potent osteoinductive oxysterol being developed as a device (OxyFuse-133®) for stimulation of bone formation in spine fusion procedures, and Oxy210, a drug-like oxysterol with robust anti-fibrotic and anti-inflammatory properties, that is being developed for treatment of non-alcoholic steatohepatitis (NASH), also known as metabolic dysfunction associated steatohepatitis (MASH) and associated metabolic disorders, including atherosclerosis, and chronic inflammation. Other opportunities lie with oxysterol-based molecules that display anti-inflammatory, anti-cancer and anti-viral properties.

Primary Focus

Pipeline-Primary Focus

Other Opportunities

Other Fibrotic Disorders

Lung & Kidney Fibrosis

Other Fibrotic Disorders

Oxy210 shows promise in cellular models of lung and kidney fibrosis. Through collaborations with outside expert scientists, we are examining the potential of Oxy210 for treating other fibrosis disorders, including idiopathic pulmonary fibrosis (IPF).

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Chronic Inflammation

Inflammaging , Obesity

Chronic Inflammation

Chronic inflammation is an underlying driver of many human diseases, including cardiovascular disease, non-alcoholic steatohepatitis (NASH), psoriasis, arthritis, cystic fibrosis, and others. With increasing age, low grade inflammation in many tissues and organs may become chronic and non-resolving, a problem sometimes referred to as “inflammaging”. Anti-inflammatory oxysterols may be a solution to this problem.

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Cardiovascular Disease

Atherosclerosis

Atherosclerosis

Oxy210, an orally bioavailable oxysterol-based drug candidate that inhibits liver inflammation and fibrosis, also inhibits atherosclerosis. In addition, Oxy210 significantly lowers circulating cholesterol levels.

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Oncology

Pancreatic & Lung Cancer

Oncology

Some of our oxysterol-drug candidates show promise in targeting lung and pancreatic cancer. Through collaborations with outside expert scientists, we are examining the potential of these oxysterols for targeting lung and pancreatic cancer.

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Orthopedic

Bone repair, Fracture Healing

Orthopedic

Oxy133 could provide a safe and effective alternative to bone graft materials currently in use to improve bone fracture healing and regenerate bone in trauma-induced bone defects.

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Viral Diseases

Covid- 19 & HBV

Viral Diseases

Oxysterols are known to affect viral infections, including hepatitis B virus (HBV) and coronaviruses, such as SARS-CoV-2. Through collaborations with outside expert scientists, we strive to demonstrate the potential of these oxysterols for the treatment of viral diseases.

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