Pipeline Overview
Leveraging its platform technology, Oxysterol Therapeutics®, MAX BioPharma continues to identify semi-synthetic oxysterol analogues with potential as drug candidates for treating several debilitating and fatal disorders. These oxysterols target cellular mechanisms that are drivers of human disease. Our oxysterol candidates were handpicked for superior efficacy and favorable drug-like pharmacokinetic and safety profiles. Our current lead is Oxysterol Oxy210, a drug-like oxysterol with robust anti-cancer, anti-viral and anti-bacterial properties, that is being developed for treatment of metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH) and associated metabolic disorders, including atherosclerosis, and chronic inflammation. Other opportunities lie with oxysterol-based molecules that display anti-inflammatory, anti-cancer and anti-viral properties.
Primary Focus
Other Opportunities
Fibrosis
Lung & Kidney Fibrosis
Fibrosis
Oxy210 shows promise in cellular models of lung and kidney fibrosis. Through collaborations with outside expert scientists, we are examining the potential of Oxy210 for treating other fibrosis disorders, including idiopathic pulmonary fibrosis (IPF).
Chronic Inflammation
Inflammaging , Obesity
Chronic Inflammation
Chronic inflammation is an underlying driver of many human diseases, including cardiovascular disease, metabolic dysfunction-associated steatohepatitis (MASH), psoriasis, arthritis, cystic fibrosis, and others. With increasing age, low grade inflammation in many tissues and organs may become chronic and non-resolving, a problem sometimes referred to as “inflammaging”. Anti-inflammatory oxysterols may be a solution to this problem.
Cardiovascular Disease
Atherosclerosis
Atherosclerosis
Oxy210, an orally bioavailable oxysterol-based drug candidate that inhibits liver inflammation and fibrosis, also inhibits atherosclerosis. In addition, Oxy210 significantly lowers circulating cholesterol levels.
Oncology
Pancreatic & Lung Cancer
Oncology
Some of our oxysterol-drug candidates show promise in targeting lung and pancreatic cancer. Through collaborations with outside expert scientists, we are examining the potential of these oxysterols for targeting lung and pancreatic cancer.
Orthopedics
Spinal Fusion, Bone repair, Fracture Healing
Orthopedic
Oxy133 could provide a safe and effective alternative to bone graft materials currently in use to improve bone fracture healing and regenerate bone in trauma-induced bone defects.
Microbial infections
Tuberculosis, Covid- 19, HBV
Microbial infections
Oxysterols are known to affect viral infections, including tuberculosis (TB), hepatitis B virus (HBV), and coronaviruses, such as SARS-CoV-2. Through collaborations with outside expert scientists, we strive to demonstrate the potential of these oxysterols for the treatment of viral diseases.
